Chronic low back pain (cLBP) is defined as pain in the lumbar back region that persists for 12 weeks or longer.1 It has many different causes and often presents in a non-specific manner.1,2 cLBP represents a leading cause of disability, with a pronounced impact on quality of life, and major economic and societal consequences.2


Quick facts

  • cLBP is the second leading cause of disability globally.3
  • From 2006 to 2016, the prevalence of cLBP in adults has increased by more than 100%.3
  • The staggering costs of low back pain (LBP) are comparable to other conditions such as headache, heart disease, depression and diabetes.4
  • Risk factors for cLBP include old age, weight gain, genetics and heavy lifting.1,2
  • Both nociceptive and neuropathic mechanisms play a part in most cases of cLBP.5 Therefore, this can be classified as a mixed pain syndrome.5
  • Medical history and physical examination are predominantly used to identify any serious conditions causing pain. A thorough examination of the back and neurological tests can also be conducted to determine the cause of pain and appropriate treatment.1




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  • Quellen

    1. National Institute of Neurological Disorders and Stroke. Low back pain fact sheet. 2020. Available at: Accessed June 2021.

    2. Ehrlich GE. Bull World Health Organ. 2003;81:671–6.

    3. Allegri M et al. F1000Res. 2016;5:1530.

    4. Maetzel A & Li L. Best Pract Res Clin Rheumatol. 2002;16:23–30.

    5. Morlion B. Curr Med Res Opin. 2011;27:11–33.

    6. Hoy D et al. Arthritis Rheum. 2012;64:2028–37.

    7. Meucci RD et al. Rev Saude Publica. 2015;49:1.

    8. Gore M et al. Spine. 2012;37:E668–77.

    9. Oliveira CB et al. Eur Spine J. 2018;27:2791–803.

    10. Vardeh D et al. J Pain. 2016;17(Suppl 9):T50–69.

    11. Müller-Schwefe G et al. Curr Med Res Opin. 2017;33(7):1199–210.

    12. Rasmussen C et al. Spine (Phila Pa 1976). 2005;30(21):2469–73.

    13. Varrassi G et al. Curr Med Res Opin. 2010;26:1231–45.